ABSTRACT
The invasion and metastasis of tumor as the primary cause of death in cancer increases not only the patient's suffering, but also the difficulty of clinical treatment. It is an important guiding to find the molecular biological tumor markers and gene targets of antirecurrence and antimetastasis for clinical treatment. The invasion and metastasis of tumor is a complex process including the biological characteristics of the cancer, interaction among host cells, extracellular matrix and cancer cells, etc. Recently, epithelial mesenchymal transition (EMT) is becoming a hot spot in oncology research by virtue of its effect on genesis and development of tumor. Currently, the known markers of EMT include epithelial marker proteins mainly containing E-cadherin and interstitial marker proteins mainly containing N-cadherin and vimentin. It is necessary to make a summary among the studies on three proteins.
ABSTRACT
Objective To analyze the contemporary TCM academic team of lung cancer, summarizes its main academic thoughts. Methods To represent characters, important documents, and the main academic ideas as the basis of a team. From the perspective of the literature, literature of Chinese medicine against lung cancer, adopt the method of literature metrology, and social network analysis the candidate teams were found;the method of literature investigation evaluation candidate team heritage was adopted, the main academic thoughts from each team representative was summarized. Results A total of 8 441 researchers published 5 030 papers about treatment of lung cancer with TCM. 91 researchers with large amount papers and seven academic team were found. Conclusion Chinese medicine treatment of lung cancer made a great progress in the contemporary, team enriched the TCM system of principle, method, square, medicine.